Both images show individual red blood cells. The one on the right, produced by STED, more clearly shows the Piezo1 proteins (in green), which are a mechanical calcium channel and play a crucial role ...

Confocal microscopy is a powerful and versatile technique for studying biological phenomena on scales ranging from tissue-level structures to subcellular details. Conducting microscopy experiments ...

Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

A decade ago, the Nobel Prize in Chemistry was awarded to a trio of researchers for the development of super-resolved fluorescence microscopy. The announcement at the time stated that the researchers’ ...

In life sciences, confocal fluorescence microscopy (CFM) is widely regarded for producing high-resolution cellular images. However, it requires fluorescent staining, which poses risks of ...

eDL-cSIM: An AI-driven super-resolution imaging method that captures high-quality live-cell dynamics in a single exposure, enhancing speed, resolution, and environmental robustness for advanced ...

A dedicated bioimaging function at GSK has shown how integrated microscopy and analytics can deliver quantitative evidence ...

Example of super-resolution microscopy: The image shows how the Discrete Molecular Imaging (DMI) technology visualizes densely packed individual targets that are just 5 nanometer apart from each other ...

Super-resolution microscopy, or nanoscopy, enables the use of fluorescent-based molecular localization tools to study molecular structure at the nanoscale level in the intact cell. Analysis of ...

Structured illumination microscopy (SIM) is the most preferable system for live-cell super-resolution imaging. It enables the observation of intricate subcellular dynamics. However, conventional SIM ...

Computational methods and algorithmic data processing are an important aspect of super-resolution microscopy, but a new approach to the task could offer a route to enhanced imaging. Generative AI is ...