Peptide synthesis can be described as a multistep process consisting of the synthesis of partially protected amino acids, activation of the reactive group, along with coupling and final …

Peptide scientists still have a number of synthetic challenges to address including the synthesis of long peptides, bicyclic peptides, pegylated peptides, lipopeptides, glycosylated peptides, cell …

Peptide synthesis is defined as the formation of a peptide chain through the successive addition of amino acids, which involves a carbon-nitrogen bond-forming reaction essential for producing …

Nov 20, 2024 · Here, we disclose the first example of amide and peptide synthesis through Ni-catalyzed cross-reductive coupling of electrophile aminating reagents and carboxylic acids. …

Jul 1, 2023 · Abstract Background Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the …

Mar 1, 2025 · The integration of low-frequency ultrasound with Solid-Phase Peptide Synthesis (SPPS) was explored to establish a Sustainable Ultrasound-assisted Solid-Phase Peptide …

May 15, 2025 · Challenge: advances in peptide synthesis and screening methodologies suggest that larger and more diverse catalyst libraries are on the horizon. However, the field must …

Apr 1, 2023 · The designed TaPSy system can produce peptides with high purity (>70%), even with the green GVL solvent alternative. In this paper we demonstrate the optimization path of a …

Feb 1, 2025 · Nonetheless, computational peptide design remains difficult, hindered by the intrinsic flexibility of peptides and the substantial computational resources required. Recent …

Apr 15, 2025 · Abstract Semaglutide and liraglutide are long-acting glucagon-like peptide-1 receptor agonists used to treat type-2 diabetes and obesity. Recent advances in peptide …